It depends on how much modifications you're going to make. If its anything like Divine Right then you'd have to use MPQdraft. New skins and new models (and terrain) can all be handled by the campaign editor/import manager.
Rok= Rise of Krill
Divine right = well... i dunno but its prolly some mod
and to make one... get 15 extra hours in the day and try and find people that will help you, and stick with you, lol good luck if ur thinking bout making one :D