Memory leaks when destroying items?

Is there a particular reason to avoid creating and destroying large numbers of items in a map- because this happens to be exactly what I'm doing as part of my Majesty mod's interface (using the inventory panel as an auxiliary unit UI.) Is there some reason that items are particuarly susceptible to memory leaks, which I need to watch out for?
Sorry if this seems somehwat vague, but I was just curious.